When should a pulse check be performed during CPR with an AED in use?

The optimal time to perform a pulse check during CPR with an AED in use is after observing that the patient is breathing on their own. This indicates that normal circulatory function is potentially being restored. If the individual is breathing independently, it suggests that their heart is likely pumping blood effectively, which is a key indicator of return of spontaneous circulation (ROSC).

During CPR, continuous chest compressions are prioritized to maintain blood flow, and pulse checks are typically performed only when there are signs of recovery, such as normal breathing. Checking for a pulse too frequently can disrupt the rhythm of compressions and negatively impact the efficacy of resuscitation efforts. Thus, a pulse check should generally be avoided until there are signs of adequate circulation, including spontaneous breathing.

In the context of the other options, checking a pulse after administering breaths, after the AED indicates "no shock advised," or after two minutes of compressions does not directly correlate with a reliable indication of return of circulation as efficiently as the presence of independent breathing does.